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| Immune System Expert Dr. Dipnarine Maharaj MD - Stem Cell Transplant Physician |
Wednesday, September 25, 2013
Immune System Expert Dr. Dipnarine Maharaj MD - Stem Cell Transplant Physician
Thursday, August 22, 2013
Scientists give grubby children a clean bill of health
Scientists give grubby children a clean bill of health
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Getting dirty as a child may well be the answer to a healthier, allergy-free life, according to researchers in California. Photograph: Gerard Fritz/Rex Features For parents too stretched to make sure their offspring are perfectly turned out at all times, it may just be the scientific cover they've been waiting for.They will now be able to answer the disapproving tuts of their more fastidious friends by pointing to research which gives biological backing to the old adage that the more germs a child is exposed to during early childhood, the better their immune system in later life
Researchers from the School of Medicine at the University of California found that being too clean could impair the skin's ability to heal. The San Diego-based team discovered that normal bacteria that live on the skin trigger a pathway that helps prevent inflammation when we get hurt.
These bugs dampen down overactive immune responses which can cause cuts and grazes to swell, or lead to rashes, according to research published in the online edition of Nature Medicine.
"These germs are actually good for us," said Professor Richard Gallo, who led the research. Common bacterial species, known as staphylococci, which can cause inflammation when under the skin, are "good bacteria" when on the surface, where they can reduce inflammation.
By studying mice and human cells, researchers discovered that they did this by making a molecule, called lipoteichoic acid (or LTA) , which acted on keratinocytes, the main cell types found in the outer layer of the skin.
The findings bear out the "hygiene hypothesis", first proposed in the 1980s, which suggests that early childhood exposure to bugs might "prime" the immune system to prevent allergies. It has been used to explain why increasing numbers of children in developed countries, where antibacterial sprays and wipes are common, suffer from allergies such as hay fever and eczema. "The exciting implication of the work is that it provides a molecular basis to understand the hygiene hypothesis," said Prof Gallo. "This may help us to devise new therapeutic approaches for inflammatory skin diseases".
According to Allergy UK, rates of allergy trebled in the UK in the last decade, with one in three suffering.
The pressure group Parents Outloud, which campaigns to stop children being "mollycoddled" and "oversanitised" by health and safety regulations, welcomed the research. "Hopefully research like this will help parents realise that it's natural and healthy for children to get outdoors and get mucky and that it doesn't do their health any harm," said a spokeswoman, Margaret Morrissey.
http://www.theguardian.com/society/2009/nov/23/grubby-children-scientists-immune-system
Monday, August 19, 2013
Immune system boost 'fights cancer'
Immune system boost 'fights cancer'
Researchers carried out the tests on a type of lung
cancer
A way of firing up the body's immune
system in order to attack cancer has been discovered by US researchers.
The immune system is delicately balanced so it attacks invaders but not the body's own tissues.
Animal studies suggested that shifting the balance could open up new treatments for cancer, the team from the Children's Hospital of Philadelphia said.
The findings were published in Nature Medicine.
There are many diseases caused by the immune system turning on the body's own tissues - such as type 1 diabetes or multiple sclerosis.
'New cancer immunotherapy'
One popular area of research in both cancer and autoimmune diseases has been Treg cells.
They are a part of the immune system which normally calm everything down to prevent the immune system attacking the body.
The researchers were trying to disrupt Treg's function - effectively taking the brakes off the immune system - so it would attack cancer.
One of the researchers, Dr Wayne Hancock, said: "We needed to find a way to reduce Treg function in a way that permits antitumor activity without allowing autoimmune reactions."
The researchers bred mice which lacked a chemical needed for Tregs to work effectively. They then used a drug which produced the same effect in normal mice.
In both experiments, the shift in the immune system restricted the growth of a type of lung cancer.
"It really moves the field along towards a potentially major, new cancer immunotherapy," Dr Hancock said.
However, this is still a long way from any treatment for patients with cancer. Further tests will be needed to see if the same processes can be manipulated in the human immune system before it could even be tested in clinical trials.
Dr Emma Smith, from Cancer Research UK, said: "Turning the power of our immune system against cancer is a promising field of research and something scientists around the world, including our own, are studying.
"These findings go another step towards developing new treatments that act in this way, but the research is still at an early stage and we don't know yet whether this approach will be safe or effective in people."
Dr. Dipnarine Maharaj, a hematologist and oncologist from Boynton Beach Florida, was quick to remind everyone that human trials were already going on with immunotherapy for cancer patients.
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| Dr. Dipnarine Maharaj MD - Cancer and Immune System Specialist |
"We have an FDA approved Phase I/Phase II Clinical trial for cancer patients with solid tumors. We are treating them with the immune systems (white blood cells) of young healthy donors. We believe that this represents the future of how we treat diseases," stated Maharaj.
Dr. Maharaj's immunotherapy cancer clinical trial has gained recognition from many media sources including Suzanne Somers, who interviewed Dr. Maharaj and spoke about his research on the TODAY show with Savannah Guthrie.
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Immune System Optimization
Immune System Optimization
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